Cancer Cachexia

نویسنده

  • Renata Dobrila Dintinjana
چکیده

Cancer anorexia-cachexia (CACS) is defined as a multifactorial syndrome characterized by ongoing loss of skeletal muscle mass that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment [1]. Cancer cachexia occurs across a continuum, varying in severity and stage; according to new classification we have pre-cachexia (early clinical signs of cachexia, low-grade weight loss), which may progress to cachexia (weight loss >5% in the last 6 months or a combination of >2% weight loss with low muscle or low BMI), and refractory cachexia (occurs due to rapidly progressing disease, and is unresponsive to anti-cancer therapy) [2-4]. CACS cannot be reversed by conventional nutritional support. The highest prevalence of this syndrom is seen in patients suffering from gastrointestinal and head and neck cancers (up to 90% of cases) [3-5].

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تاریخ انتشار 2015